GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9815354 | 1 | rs7648357 | chr3:41849670 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.03 | 1.21E-8 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs7648578 | chr3:41858731 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.25 | 3.87E-9 | Diastolic blood pressure |
| UCEC | cis | rs10935120 | 1 | rs7648990 | chr3:134244390 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs9815354 | 1 | rs7650227 | chr3:41794937 | ULK4 | chr3:41288091-42003660:- | 0.49 | 5.86 | 2.82E-8 | Diastolic blood pressure |
| UCEC | cis | rs11782652 | 1 | rs76837345 | chr8:82668818 | CHMP4C | chr8:82644688-82671746:+ | -1 | -4.47 | 1.51E-5 | Epithelial ovarian cancer;Ovarian cancer |
| UCEC | cis | rs1432723 | 1 | rs76989382 | chr5:155315647 | PPP1R2P3 | chr5:156277549-156279539:+ | 0.42 | 4.67 | 6.67E-6 | Obesity-related traits |
| UCEC | cis | rs7705093 | 1 | rs7705093 | chr5:96290647 | ERAP2 | chr5:96211644-96255398:+ | 0.96 | 16.51 | 9.82E-36 | Birdshot chorioretinopathy |
| UCEC | cis | rs1577917 | 1 | rs7747824 | chr6:86647106 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.77 | 4.28E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs9473555 | 1 | rs7750918 | chr6:49430082 | MUT | chr6:49398994-49431031:- | 0.38 | 6.33 | 2.55E-9 | Folate pathway vitamin levels |
| UCEC | cis | rs1577917 | 1 | rs7756203 | chr6:86627707 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs7760207 | chr6:86721700 | SNHG5 | chr6:86386726-86388451:- | -0.47 | -5.84 | 3.13E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs7766645 | chr6:86622238 | SNHG5 | chr6:86386726-86388451:- | -0.46 | -5.96 | 1.65E-8 | Response to antipsychotic treatment |
| UCEC | cis | rs1577917 | 1 | rs7771342 | chr6:86631936 | SNHG5 | chr6:86386726-86388451:- | -0.42 | -4.96 | 1.9E-6 | Response to antipsychotic treatment |
| UCEC | cis | rs11976180 | 1 | rs7777389 | chr7:143744802 | ARHGEF35 | chr7:143883677-143892736:- | -0.43 | -4.54 | 1.13E-5 | Obesity-related traits |
| UCEC | cis | rs11782652 | 1 | rs78724141 | chr8:82659661 | CHMP4C | chr8:82644688-82671746:+ | -1.02 | -4.68 | 6.23E-6 | Epithelial ovarian cancer;Ovarian cancer |